Preliminary animal studies do not show any harmful effects in pregnancy, however data on the use of Vaxzevria during pregnancy are very limited. 16 paid holidays, including floating holidays. We encourage you to read the privacy policy of every website you visit. Join us today! Company Secretary AstraZeneca PLC. You have selected a link that will take you to a site maintained by a third party who is solely responsible for its contents. Trash and recycling pickups are delayed in some neighborhoods during the holiday week. I have read this warning and will not be using any of the contained product information for clinical purposes. These studies involved around 24,000 people altogether. The study also showed that the vaccine efficacy of Vaxzevria in older people is comparable to that seen in younger people. Thrombosis (formation of blood clots in the blood vessels) in combination with thrombocytopenia (thrombosis with thrombocytopenia syndrome, TTS) and Guillain-Barr syndrome (a neurological disorder in which the bodys immune system damages nerve cells) may affect up to 1 in 10,000 people. This means that the vaccine demonstrated around a 60% efficacy in these clinical trials. The treatment rivals GlaxoSmithKline's (GSK.L) Nucala and Teva's (TEVA.TA) Cinqair from the same drug class, while AstraZeneca has also developed a newer medicine, Tezspire, with Amgen (AMGN.O) which would compete with Fasenra. AstraZeneca Vacation & Paid Time Off 319 employees reported this benefit 4.5 43 Ratings Available to US-based employees Change location Employee Comments Showing 1-10 of 43 Jan 13, 2023 5.0 Former Sr. Pharmaceutical Sales Specialist in nullnull Additional weeks are added as you build up time with the company. Date Calculator - Add or subtract days, months, years Join an environment where you can thrive professionally and be inspired personally. The European Medicines Agency decided that Vaxzevrias benefits are greater than its risks and it can be authorised for use in the EU. Helpful Report Jun. 09/02/2023 Vaxzevria (previously COVID-19 Vaccine AstraZeneca) - EMEA/H/C/005675 - II/0084/G. [1/2]The logo of AstraZeneca is seen on a medication package in a pharmacy in London April 28, 2014. Novartis assumes no responsibility to update the information to reflect subsequent developments. Once it has been given, the vaccine delivers the SARS-CoV-2 gene into cells in the body. Our ongoing commitment to inclusion and diversity means we're future proofing our business. 9 Feb 2022. In July 2022, HyCC Holding's subsidiary HyCC BV (Hydrogen Chemistry Company/2020-founded joint venture of Nobian and GIG-Green Investment Group) launched "Project H2era" (500-MW green hydrogen plant in the Port area) planned for . Here is a detailed 2023 / 2024 / 2025 China public holiday schedule for your reference: List of National Public Holidays of China in 2023 / 2024 / 2025 . First published: 12/08/2022 EMA/666408/2022 Vaxzevria (previously COVID-19 Vaccine AstraZeneca)-H-C-5675-II-0052 : EPAR - Assessment report - Variation (PDF/6.59 MB) Adopted First published: 04/08/2022 EMA/351687/2022 Vaxzevria (previously COVID-19 Vaccine AstraZeneca)-H-C-5675-R-0037 : EPAR - Assessment report - Renewal (PDF/425.05 KB) Adopted AstraZeneca provides this link as a service to website visitors. As for all vaccines, Vaxzevria should be given under close supervision with appropriate medical treatment available. Clinical Trials Appendix Q4 2022 Results Update Upcoming pipeline catalysts: 2023 and 2024 . Virtual / San Francisco, USA, Access our interactive slide deck (PDF98MB), English (PDF0.2MB)|Deutsch (PDF0.2MB)|Franais (PDF0.3MB), Novartis ESG Update - October 28, 2020 (PDF0.5MB), Novartis ESG Update -July 24, 2020 (PDF0.6MB), English (PDF0.1MB)|Deutsch (PDF0.1MB)|Franais (PDF0.2MB), Download the Annual Report 2019 (PDF4MB). Pharmaceutical Sales Specialist salaries ($74k), Pharmaceutical Sales Representative salaries ($65k), Pharmaceuticals Sales Representative jobs, Pharmaceuticals Sales Representative salaries ($68k), Diabetes Sales Specialist salaries ($72k), Pharmaceuticals Sales Specialist salaries ($74k), Senior Research Scientist salaries ($100k). Media release:English (PDF0.3MB) | Deutsch (PDF0.3MB) | Franais (PDF0.3 MB), Novartis ESG Update - October 31, 2022 (PDF0.5MB), August 25, 2022 Glassdoor is your resource for information about the Paid Holidays benefits at AstraZeneca. Add to Calendar; 7 Dec. Conference, Berenberg, European Conference [IR] Add to Calendar; 2 Dec. Conference, SG Securities, The Premium Review [management] . A summary of the RMP is available. These showed a 59.5% reduction in the number of symptomatic COVID-19 cases in people given the vaccine (64 of 5,258 got COVID-19 with symptoms) compared with people given control injections (154 of 5,210 got COVID-19 with symptoms). This is a protein on the surface of the SARS-CoV-2 virus which the virus needs to enter the bodys cells. Click cancel to return to AstraZenecas site or continue to proceed. Any reference in these archives to AstraZeneca products or their uses may not reflect current medical knowledge and should not be used as a source of information on the present product label, efficacy data or safety data. In middelbaar beroepsonderwijs - MBO (secondary vocational education) and tertiary education institutions are free to set their own holiday dates.. School holidays 2022-2023 Please do not include any personal data, such as your name or contact details. AstraZeneca Paid Holidays 99 employees reported this benefit 4.6 18 Ratings Available to US-based employees Change location Employee Comments Showing 1-10 of 18 Oct 11, 2022 5.0 Current Employee It's Industry standard for holidays. The setback for AstraZeneca's Fasenra comes after the drugmaker said on Friday the FDA had approved its and Merck's (MRK.N) cancer drug, Lynparza, as a treatment for patients with early-stage breast cancer with certain mutations. Build the strongest argument relying on authoritative content, attorney-editor expertise, and industry defining technology. Combined results from 4 clinical trials in the United Kingdom, Brazil and South Africa showed that Vaxzevria was safe and effective at preventing COVID-19 in people from 18 years of age. Copyright 20082023, Glassdoor, Inc. "Glassdoor" and logo are registered trademarks of Glassdoor, Inc. Current Business Support Coordinator in Gaithersburg, MD, Maryland, Current Director in Wilmington, DE, Delaware, Former Outside Sales Representative in New York, NY, New York State, company-updates.categories.diversity-and-inclusion. Any reference in these archives to AstraZeneca products or their uses may not reflect current medical knowledge and should not be used as a source of information on the present product label, efficacy data or safety data. Access unmatched financial data, news and content in a highly-customised workflow experience on desktop, web and mobile. EMA has agreed with the company on a plan to conduct trials involving children at a later stage. On par with other companies I worked for. Our country sites can be located in the AZ Network. We push the boundaries of science to deliver life-changing medicines, National Kidney Month Speaking with Your Doctor about CKD, Lets Talk About Cholangiocarcinoma Awareness Month, Alexion advances commitment to transform patient outcomes in rare neurological diseases at AAN 2023, AstraZeneca and Merck present final results of key secondary overall survival endpoint from Phase III PROpel trial at ASCO GU Cancers Symposium. Daytime street cleaning is canceled, but overnight street cleaning is on a normal schedule. It just reduces the last paycheck of the Year by a corresponding amount. Click the 'Global site' link for the directory of country sites. | March 3, 2023 . . In addition, as the vaccine was to be given as two standard doses, and the second dose should be given between 4 and 12 weeks after the first, the Agency concentrated on results involving people who received this standard regimen. 18 Nov 2021. 7 Apr 2022. Our Standards: The Thomson Reuters Trust Principles. Please refer to your approved national product label (SmPC) for current product information. Additionally . This document has been updated: Version 15 March 2022.For translations of this document in other languages, clickhere. Not only was this a great event to help women build their networks at AZ, but a way for us to support women in the community by donating cribs and blankets to a local charity Rosalie Hall. We encourage you to read the privacy policy of every website you visit. Monday, December 26, 2022 - Christmas Day (Observed) City offices, Boston Public Libraries, and BCYF Community Centers are closed. Want to start your career at the cutting-edge of medical innovation? Basel, SwitzerlandWatch the webcast, Read the media release: English | Deutsch, July 19, 2022 Additionally, recent encouraging data for several of our pipeline programmes have given us the confidence to proceed with additional late-stage clinical trials as we maintain our focus on delivery of our growth ambitions. Its a lofty ambition. They may affect more than 1 in 10 people. Vaxzevria (previously COVID-19 Vaccine AstraZeneca). The London-listed drugmaker said the U.S. Food and Drug Administration (FDA) had issued a complete response letter following AstraZeneca's application to extend use of the treatment and requested additional clinical data from it. On par with other companies I worked for. A risk management plan for Vaxzevria is also in place and contains important information about the vaccines safety, how to collect further information and how to minimise any potential risks. Basel, Switzerland And work with some of the brightest minds in the industry who will push you to be your best? Learn about AstraZeneca Vacation & Paid Time Off, including a description from the employer, and comments and ratings provided anonymously by current and former AstraZeneca employees. 2 weeks and week after Christmas, 15 days vacation and 3 days floating holiday and 11 public holiday. Although immunocompromised people may not respond as well to the vaccine, there are no particular safety concerns. It belongs to a class of medicines called monoclonal antibodies and is used against severe asthma. Our country sites can be located in the AZ Network. Conference, Cowen, 43rd Annual Health Care Conference [Management], Conference, Bank of America, Bus Tour [Management], Conference, Carnegie, Healthcare Seminar [Management], Conference, Kepler Cheuvreux, One-Stop Shop Luxembourg [IR], Conference, Berenberg, UK Corporate Conference 2023 [Management], Roadshow, Danske Bank, Copenhagen [Management], Roadshow, Citibank, San Francisco / Virtual [Management], Roadshow, Cowen, Baltimore / Virtual [Management], Roadshow, J P Morgan, London / Virtual [Management], Roadshow, Citibank, San Francisco [Management], Roadshow, J P Morgan, London [Management], Roadshow, Citibank, Los Angeles [Management], Conference, JP Morgan Healthcare Conference [Management], Meet AZN Management: SABCS (San Antonio Breast Cancer Symposium) 2022, Conference, Berenberg, European Conference [IR], Conference, SG Securities, The Premium Review [management], Virtual conference, Redburn, 10th Annual CEO Conference [management], Conference, Goodbody, 15th Annual Equity Conference [IR], Fireside chat, SEB Annual Healthcare Seminar [Management], Conference, Jefferies, 13th Annual Healthcare Conference [management], Virtual conference, Wolfe Research, Healthcare Conference [management], Virtual conference, Berenberg, Pharma CFO Series [management], Bus Tour, Citi, European Healthcare Bus Tour [management], Conference, Bernstein, 19th Pan European Annual Strategic Decisions Conference [management], Bus Tour, Credit Suisse, European Investor Bus Trip [management], Conference, Morgan Stanley, 20th Annual Global Healthcare Conference [management], Conference, Bank of America, Global Healthcare Conference 2022 [management], Virtual conference, Jefferies, Back to School Fireside chat [management], Conference, Kepler Cheuvreux, Autumn Conference [management], Meet AZN management: European Society of Medical Oncology 2022 Annual Meeting, Virtual call, Deutsche Bank ESMO Oncology Call [management], Virtual conference, Morningstar, Management Behind the Moat Conference [management], Virtual conference, J.P. Morgan, European CEO Call Series [management], Meet AZN Management: Alexion Rare Disease Deep Dive, Conference, Berenberg, Copenhagen Top Picks Seminar [IR], Virtual bus tour, Cowen, Hot Wheels [management], Virtual roadshow, Citi, West Coast [management], Virtual roadshow, Cowen, East Coast [management], Roadshow, Citi, San Francisco [management], Roadshow, Deutsche Bank, Zurich [management], Roadshow, Morgan Stanley, London [management], Roadshow, Deutsche Bank, Frankfurt [management], Roadshow, Bryan Garnier, Paris [management]. Several paid holidays off, provided by company. The other two studies had fewer than 6 COVID-19 cases occurring in each, which was not enough to measure the preventive effect of the vaccine. This recognition is a direct result of her contribution to translational medicine during her time with us and her commitment to a voluntary secondment. The most common side effects with Vaxzevria are usually mild or moderate and get better within a few days after vaccination. India Post, Ministry of Communication & Technology. See here for a complete list of exchanges and delays. This medicine is authorised for use in the European Union. The study showed a 74% reduction in the number of symptomatic COVID-19 cases in people given the vaccine (73 of 17,662 got COVID-19 with symptoms) compared with people given control injections (130 of 8,550 got COVID-19 with symptoms). 2022. Suspected side effects reported with Vaxzevria are carefully evaluated and any necessary action taken to protect patients. Fasenra was AstraZeneca's first respiratory biologic and raked in $1.26 billion in sales in 2021, jumping 33% from the previous year. These WHO interim recommendations on the use of the Astra Zeneca Oxford University AZD1222 vaccine against Covid-19 were developed on the basis of advice issued by the Strategic Advisory Group of Experts on Immunization (SAGE) and the evidence Veeva ID: Z4-46798Date of next review: August 2024. Add to Calendar; 16 Feb. Roadshow, Exane, Milan [Management] . Most City offices are closed on the weekend. Parking meters are free with no time limit. At AstraZeneca, our mission is to create an inclusive and equitable environment, where people feel they belong. Version 10 February 2021, Interim recommendations for use of the ChAdOx1-S [recombinant] vaccine against COVID-19 (AstraZeneca COVID-19 vaccine AZD1222 Vaxzevria, SII COVISHIELD). These WHO interim recommendations on the use of the Astra Zeneca - Oxford University AZD1222 vaccine against Covid-19 were developed on the basis of advice issued by the Strategic Advisory Group of Experts on Immunization (SAGE) and the evidence summary included in the background document referenced below. You are about to access AstraZeneca historic archive material. Vaxzevria is indicated for active immunisation to prevent COVID 19 caused by SARS CoV 2, in individuals 18 years of age and older. Annual Report 2022 publication. All quotes delayed a minimum of 15 minutes. For the United Kingdom, as of 1 January 2021, European Union law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland / NI. Although there are no studies on breast-feeding, no risk during breast-feeding is expected. Jan 6 - Thurs. Listen to Yossra's video to find out what she enjoys about working with us . Any reference in these archives to AstraZeneca products or their uses may not reflect current medical knowledge and should not be used as a source of information on the present product label, efficacy data or safety data. When autocomplete results are available use up and down arrows to review and enter to select. 2022 . You have selected a link that will take you to a site maintained by a third party who is solely responsible for its contents. Click below to read more about this next chapter. The clinical trial included people of different ethnicities and genders. read more. The vaccines should be used according to official recommendations issued at national level by public health bodies. We want to transform healthcare, change the lives of billions of people for the better and address some of the biggest healthcare challenges facing humankind. Vaxzevria is given as two injections, usually into the muscle of the upper arm. The second dose should be given between 4 and 12 weeks after the first dose. Monday, December 26, 2022 -Christmas Day (Observed), Monday, January 2- New Year's Day (Observed), Monday, January 16 -Martin Luther King, Jr. Day, Monday, October 9 -Indigenous Peoples Day. This website is intended for people seeking information on AstraZeneca's worldwide business. The AstraZenecaCOVID-19 vaccine is available for those aged 18 and older who cannotreceive the Pfizer vaccine, and for people who would like a different option. Vaxzevria is a vaccine for preventing coronavirus disease 2019 (COVID-19) in people aged 18 years and older. Credit Suisse Annual General Meeting 2023. Thrombocytopenia (low levels of blood platelets), vomiting, diarrhoea, pain in legs or arms, swelling and redness at the injection site, flu-like illness and asthenia (weakness) may affect up to 1 in 10 people. Learn about AstraZeneca Paid Holidays, including a description from the employer, and comments and ratings provided anonymously by current and former AstraZeneca employees. The information provided is from their perspective. People who have a severe allergic reaction when they are given the first dose of Vaxzevria should not receive the second dose. Italian state investor CDP has called a board meeting on Sunday which is expected to approve a long-delayed non-binding offer for the fixed network of former phone monopoly Telecom Italia , three sources close to the matter said. 7 February 2023 Addressing Chronic Kidney Disease Through Prevention, Detection, and Management 15 December 2022 Latest News from AstraZeneca US AstraZeneca and Merck present final results of key secondary overall survival endpoint from Phase III PROpel trial at ASCO GU Cancers Symposium 23 January 2023 This holiday honors Christopher Columbus. There is just one federal holiday in October: Columbus Day. Hear from Yossra as she describes what she enjoys about working here. Add To Calendar Apr 4 2023 . This website is intended for people seeking information on AstraZeneca's worldwide business. Financial Calendar. Important notice for users Vaxzevria works by preparing the body to defend itself against COVID-19. Version 21 April 2021, Interim guidance for the useof the Astra Zeneca Oxford University AZD1222 vaccine against Covid-19. Moon Phase Calendar - Calculate moon phases for any year. Amsterdam cruise port schedule 2023-2024-2025, map, address, ship terminals, hotels, tours, shore excursions. Allergic reactions have occurred in people receiving the vaccine, including some cases of severe allergic reactions (anaphylaxis). Ordinary: 23p ADR: $0.6034528. #astrazeneca #RosalieHall. The cells will use the gene to produce the spike protein. Duration Between Two Dates - Calculates number of days. The most comprehensive solution to manage all your complex and ever-expanding tax and compliance needs. Leading up to the holiday season, close to 100 AstraZeneca women and allies came together for our Network of Women team building event to construct cribs and blankets. Below you can find a list of City-recognized holidays during the year. Your response will be removed from the review this cannot be undone. The most common side effects are tenderness, pain and bruising at the injection site, headache, tiredness, muscle pain, general feeling of being unwell, chills, fever, joint pain and nausea (feeling sick). The adenovirus in the vaccine cannot reproduce and does not cause disease. summary included in the background document referenced below. AstraZeneca begins tender offer to acquire CinCor Pharma, Inc. AIRSUPRA (PT027) approved in the US for asthma, First participant dosed in SUPERNOVA Phase I/III trial evaluating AZD5156, a next-generation long-acting antibody combination, for prevention of COVID-19, Transparency in Coverage - Machine Readable Files. Most popular. The name of the vaccine was changed to Vaxzevria on 25 March 2021.The conditional marketing authorisation was switched to a standard marketing authorisation on 31 October 2022. Available to US-based employeesChange location, Significant amount of paid yearly holidays (16), Good paid holidays and time off for cleaning. Vaxzevria is made up of another virus (of the adenovirus family) that has been modified to contain the gene for making a protein from SARS-CoV-2, the virus that causes COVID-19. The efficacy was maintained across genders and ethnic groups. Disclaimer: The information in the presentations on these pages was factually accurate on the date of publication. If, later on, the person comes into contact with SARS-CoV-2, their immune system will recognise it and be ready to defend the body against it. CET . But we know that as with every great journey, the road always starts with oneone indication that can change the course of disease for a patient, one person living with cancer that benefits from our support services, one access barrier that we can help to overcome, one system to transform in partnership with the communityand then another, building from there until success is achieved. Your response will be removed from the review this cannot be undone. AstraZeneca provides this link as a service to website visitors. For more information, see Medicines under additional monitoring. In addition, the company has completed all requested studies on the pharmaceutical quality of the vaccine. AstraZeneca is a global biopharmaceutical company pushing the boundaries of science to discover and develop new lifechanging medicines More. AstraZeneca is not responsible for the privacy policy of any third party websites. It is made up of another virus (adenovirus) that has been modified to contain the gene for making the SARS-CoV-2 spike protein. If you are passionate about science, these stories will show you how the latest and most exciting projects we have been working on and the people behind them. At AstraZeneca, we believe that building an inclusive culture and leveraging the strength and diversity of our people will provide a More. Our purpose is simple: push the boundaries of science to deliver life-changing medicines. This is the employer's chance to tell you why you should work for them. The participants received the second dose 4 weeks after the first one. Further data showed a rise in antibody levels when a booster dose was given after the second dose of Vaxzevria or after two doses of an mRNA vaccine in adults aged 30 years and above with a normal immune system. This site is intended for a global audience, Diversity, Equity & Inclusion Governance and Community, Novartis Commitment to Patients and Caregivers, Novartis Gene Therapies Managed Access Program, Healthcare Professional Resources by Country, Novartis Institutes for BioMedical Research, Cardiovascular and metabolic disease research at Novartis, Autoimmunity, transplantation and inflammatory disease research at Novartis, Musculoskeletal Disease Research at Novartis, DAx: exploratory disease research at Novartis, Community Exploration & Learning Lab (CELL). A booster dose may be given at least 3 months after the second dose. City offices, Boston Public Libraries, and BCYF Community Centers are closed. Our US business showcases the best of AstraZeneca with a combination of cutting-edge R&D and high-performance operations. A very small number of cases of angioedema (rapid swelling under the skin), capillary leak syndrome (fluid leakage from small blood vessels causing tissue swelling and a drop in blood pressure) and transverse myelitis (a neurological condition characterised by an inflammation in the spinal cord) have occurred with Vaxzevria. CEST . Click cancel to return to AstraZenecas site or continue to proceed. Our country sites can . Click cancel to return to AstraZenecas site or continue to proceed. At AstraZeneca, we appreciate hearing why our employees enjoy working with us. To unleash creative ideas that stand out in a global market leader? See here for a complete list of exchanges and delays. Epiphany 2022. These presentations remain on the Novartis website for historical purposes only. Orthodox Christmas Day 2022. Please refer to your approved national product label (SmPC) for current product information. Vaxzevria offers a good level of protection against COVID-19 which is a critical need in the current pandemic. Immunocompromised people can still be vaccinated as they may be at higher risk from COVID-19. Available to US-based employeesChange location. People who already know they have an allergy to one of the components of the vaccine listed in section 6 of the package leaflet should not receive the vaccine. Find information on upcoming and past events in our corporate calendar. Festival Date 2023 days off 2024 days off 2025 days off; New Year's Day: Jan. 1: Dec. 31, 2022 - Jan. 2, 2023: Dec. 30, 2023 - Jan. 1, 2024: Jan. 1: Chinese New Year: in Jan. or Feb. Jan. 22 . Fourth quarter and full year results 2022 and Annual Report 2022 publication February 01, 2023 | Basel, Switzerland Media release: English (PDF 0.3 MB) | Deutsch (PDF 0.3 MB) | Franais (PDF 0.3 MB) Condensed financial report (PDF 0.5 MB) Watch the webcast Download the presentation (PDF 5.1 MB) Download the podcast (MP3 45 MB) As for all medicines, data on the use of Vaxzevria are continuously monitored. AstraZeneca is not responsible for the privacy policy of any third party websites. Huge congratulations to one of our apprentice Shaan Gill who has just received a Highly Commended award from the Royal Society of Biology. Calendar for 2023; Calendar for 2024; Calendar Generator - Create a calendar for any year. Christian. Pharmaceutical Sales Representative salaries ($78k), Administrative Coordinator salaries ($52k). Show All Holidays for 2023. Please refer to your approved national product label (SmPC) for current product information. 24 Feb 2022. Cases of anaphylaxis (severe allergic reaction) have also occurred. You have selected a link that will take you to a site maintained by a third party who is solely responsible for its contents. Half received the vaccine and half were given a control injection, either a dummy injection or another non-COVID vaccine. 2022 Total. 2030 Holiday Schedule; Date Holiday; Tuesday, January 01 : New Year's Day: Monday, January 21 : Birthday of Martin Luther King, Jr. Monday, February 18 * Washington's Birthday: . Reuters, the news and media division of Thomson Reuters, is the worlds largest multimedia news provider, reaching billions of people worldwide every day. City offices, Boston Public Libraries, and BCYF Community Centers are all open. Vaxzevria does not contain the virus itself and cannot cause COVID-19. Vaxzevria must not be given to people who have had thrombosis with thrombocytopenia syndrome (TTS) after receiving the vaccine. At AstraZeneca, we are leading a revolution in oncology to redefine cancer care for the millions of Americans living with cancer. Several paid holidays off, provided by company. The persons immune system will then recognise this protein as foreign and produce antibodies and activate T cells (white blood cells) to attack it. It allows us to push the boundaries of science and deliver life-changing medicines to more and more patients around the world. Important notice for users I have read this warning and will not be using any of the contained product information for clinical purposes. European Medicines AgencyDomenico Scarlattilaan61083 HS AmsterdamThe Netherlands. The use of this vaccine should be in accordance with official recommendations. Lymphadenopathy (enlarged lymph nodes), decreased appetite, dizziness, sleepiness, lethargy (lack of energy), hyperhidrosis (excessive sweating), abdominal (belly) pain, muscle spasms, itching, rash and urticaria (itchy rash) may affect up to 1 in 100 people. 10:30 AM - 2:00 PM.

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